H&E stain, Masson's Trichrome stain, and immunohistochemistry of the Tenon's tissue of the control group (A), POAG group (B), PACG group (C), Positive Control (D: adenocarcinoma of colon), Negative Control (E: sections were prepared with PBS instead of primary antibody MMP-1, 2, and 9) (magnification ×200)The Tenon's tissue of both the POAG and the PACG patients under H&E and Masson's trichrome staining showed higher subepithelial collagen and fibroblast density than that of the controls. The fibrosis under H&E and Masson's trichrome staining appeared to be more advanced in the POAG patients than in the PACG patients (arrow). Compared with the controls, the level of MMP-1 and 2 were higher in the POAG patients (grade 2, 3, respectively). The expression of MMP-2 was lower in the PACG patients than the POAG patients. The level of MMP-9 was less in POAG and PACG patients than the controls.
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