Effect of neferine and DOX on the pro-inflammatory transcription factor, NFκB p65 and its downstream regulators, <t>COX2</t> and TNF-α ( A ) Time dependent expression patterns of NFκB (nuclear extract) and COX2 and TNF-α (cytoplasmic extract) (0 h, 1 h, 3 h, 6 h, 12 h and 24 h). ( B ) DOX-induced nuclear translocation of NFκB, expression of COX2 and TNF-α was reduced by neferine treatment. Results were confirmed in the presence of NFκB inhibitor (QNZ). ( C ) Densitometry analysis of the protein bands of NFκB, COX2 and TNF-α. The results shown are mean ± s.d. of three individual experiments. * p
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