Impact of sirt1 siRNA on the protective role of NaHS against Dex-induced damage and senescence in osteoblastic MC3T3-E1 cells. Osteoblasts were transfected with control siRNA or sirt1 siRNA for 24 h, then subjected to treatment with vehicle; Dex and vehicle; or NaHS for 48 h. (A) Cell viability and (B) ALP activity as well as changes in the (C) mRNA and protein expression levels of sirt1 were assessed. Data are shown as the mean ± SEM (n=4). ** P
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