Immunohistochemical analysis of IL-13 and IL-13Rα1/IL-13Rα2 expression in lung tissues from patients with IPF and from controls. IL-13 was only negligibly expressed in controls (A) but was strongly expressed in the smooth muscle (B), bronchial epithelium, especially the hyperplastic regenerating epithelium (C), alveolar macrophages (D), endothelium (E), and interstitum (F) of IPF patients. IL-13Rα1 was strongly expressed by the bronchial epithelium and smooth muscle of IPF patients (G). IL-13Rα2 was weakly expressed in the same regions of IPF patients (H). Magnification: ×20 (A), ×40 (B), ×100 (C, F-H), and ×200 (D, E).
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