BACE 1 copatches with the DRM marker Thy-1 but is largely segregated from APP in the neuronal plasma membrane. Hippocampal neurons were cultured for 10 d and pairs of membrane proteins were studied by the copatching technique (see Materials and methods). (A) BACE 1 and the DRM marker Thy-1 copatch extensively, indicating that both molecules are located in membrane DRM domains (note yellow dots in the enlarged images). (B) APP and BACE 1, in contrast, appear extensively segregated.
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