Proposed Mechanism of Action of Imatinib
{"Image DocumentName": "Proposed Mechanism of Action of Imatinib", "Image ImageDescription": "Pre-imatinib. Imatinib. c-Kit Receptor. Cell membrane. Blocks ATP binding. ATP binds to kinase portion of receptor. [slide 21] Proposed Mechanism of Action of Imatinib. At the molecular level, imatinib targets a specific part of the tyrosine kinase region in Bcr-Abl, c-Kit, and PDGF-R. Proposed mechanism of action (MOA) of imatinib: Binds to c-Kit where adenosine triphosphate (ATP) normally would. Prevents the use of energy (ATP) by c-Kit. Blocks signal transduction pathways that are activated by c-Kit. Signal Transduction Pathways Inhibited. Signal Transduction Pathways Activated. Nucleus.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}