Anion Gap Described by Gamble in 1939 Electroneutrality
{"Image DocumentName": "Anion Gap Described by Gamble in 1939 Electroneutrality", "Image ImageDescription": "Na+, Cl-, and HCO3 are measured ions. Na + UC = Cl + HCO3 + UA. UC = Sum of unmeasured cations. UA = Sum of unmeasured anions. The concept of an anion gap in blood was described in 1939 by Gamble. It was felt that the law of electroneutrality required that the number of positive charges contributed by serum cations should equal the number of negative charges contributed by serum anions. Sodium (Na), chloride (Cl), and bicarbonate (HCO3) are considered the measured ions. Potassium is ignored because its value changes so little. Thus, the concept of electroneutrality can be expressed by the simple equation: Na + UC = Cl + HCO3 + UA. where UC (unmeasured cations) indicates the sum of the charges of the cations other than sodium and UA (unmeasured anions) equals the sum of the charges of all of the anions other than chloride and bicarbonate.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}