Skeletal Mass and It's Changes
{"Image DocumentName": "Skeletal Mass and It\u2019s Changes", "Image ImageDescription": "Mechanical regulation of bone biology begins at about 5-7 weeks of prenatal life when most of the adult skeletal elements and soft tissue has formed. The mechanostat best explained by Frost\u2019s hypothesis. Frost proposed the mechanostat as a name for the biologic mechanisms that skeletal mass and architecture to the needs of one\u2019s normal physical activities. It is well recognized that bone mass adapts to mechanical usage (MU) in special way: the MU makes it biologic mechanisms correct errors between the mass and its MU. MU \uf0e0 bone \uf0e0 mechanostat \uf0e0 bone mass effect. The mechanostat has been proposed to consist of at least these tissue\u2013level biologic mechansims: growth, modeling and remodeling mechanisms (location and rates) + mechanical transducers. The mechanostat concept is based on the idea that exists an effective strain, set point (range of strain at which no response), with a mechanical overload, a response will occur that increases muscle and bone mass and strength. > microstrain will evoke a positive response while <200 micostrain trigger a response that cause bone loss. So remodelling at 2 ends. Non-mechanical agents can evoke changes or errors in the set point range.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}