Actual invadopodia formation of A549 cells in control group (A), EGF group (B), and GM6001/EGF group (C) in 3D extracellular matrix in the microfluidic device with confocal system. Invadopodia could be obviously induced by EGF in (B), while this induction could be inhibited by GM6001 in (C). White arrowheads represented invadopodia. Magnification: ×1200.
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