Effects of SAHA and temperature on IPSCs mediated by α1β2γ2 N40S GABA A Rs. (A) Examples of digitally averaged and normalised IPSCs from HEK293 cells transfected with α1, β2 and γ2 N40S subunits with and without SAHA pre-application. (B–D) Effect of SAHA pre-application on the amplitudes, 10%–90% rise times and decay time constants of IPSCs mediated by α1β2γ2 N40S GABA A Rs. The control data for α1β2γ2 and α1β2γ2 N40S GABA A Rs have been replotted from Figure 1 . All data in panels (A–D) were recorded at room temperature (22°C). (E–G) Mean amplitudes, 10%–90% rise times and decay time constants of IPSCs mediated by α1β2γ2 and α1β2γ2 N40S GABA A Rs at 40°C. * p
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