Assumptions (Two-Compartment Model)
{"Image DocumentName": "Assumptions (Two-Compartment Model)", "Image ImageDescription": "k12. Vi. Vt. k21. k10. Drug in peripheral compartment (bone, fat, muscle etc.) equilibrates with drug in central compartment. Plasma, highly perfused organs, extracellular water. [C] in a given compartment is uniform. Two-compartment drugs distribute into various tissues at different, first order rates. Elimination follows a single 1st order rate process only after distribution equilibrium is reached. Different peripheral compartments will accumulate multicompartment drugs at different rates. Distribution in different compartments may be uneven, i.e., drugs generally concentrate unevenly in different groups of tissues. CP Clarke,L FD/MB", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}