Simon Mills | April 2008 21 | Packaging challenges (4FDC) A 4-API combination anti-TB tablet: Rifampicin150 mg Isoniazid 75mg Pyrazinamide400mg Ethamb
{"Image DocumentName": "Packaging challenges (4FDC)", "Image ImageDescription": "A 4-API combination anti-TB tablet: Rifampicin 150 mg. Isoniazid 75mg. Pyrazinamide 400mg. Ethambutol 275mg. TOTAL API weight: 900mg. Tablet weight: 1.3g. The technical challenges: Big tablet. Problem APIs !! \uf04c Rifampicin is vulnerable to oxidative degradation and hydrolysis, it is light sensitive and it reacts with isoniazid. It also exhibits solid-state polymorphism. \uf04c Isoniazid reacts with aldehydes/reducing sugars\u2026.& rifampicin \u2192 major degradant. \uf04c Ethambutol (2HCl) is hygroscopic, attracting moisture into the tablet to form a slightly acidic solution that encourages the rifampicin/isoniazid interaction! \uf04a Pyrazinamide\u2026..seems to be OK ! WHO thought this was a good idea?", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}