Overexpression of IκBα increases survival of v-rel transgenic  mice and changes the clinical expression. (A) Mortality curve. Deaths in  v-rel/ikba transgenic animals occurred at later times and were the result of  secondary opportunistic infection according to pathologic analysis and  microbiology. Autopsy, and histologic examination of v-rel/ikba transgenic mice revealed a less severe lymphomatous infiltrate than in v-rel  transgenic mice. n = 29 for v-rel 35, and n = 13 for v-rel/ikba. (B) T-cell  cutaneous lymphoma in v-rel/ikba double transgenic mice. All v-rel/ikba  transgenic mice developed skin lesions characterized by thickening and  exfoliative plaques. Arrow indicates a v-rel/ikba transgenic mouse; the  control mouse is an ikba transgenic littermate. (The lesions were never  observed in v-rel transgenic mice.)
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