Schematic diagram showing ADC changes with anticancer treatment. Graphs show frequency plots of ADC values in tumours before (solid black line) and after (dotted black line) therapy. Inserts depict a cluster of tumour cells, which demonstrate cellular lysis and apoptosis following treatment, thus increasing the mobility of water protons in that microenvironment. Note that successful therapy results in a shift of the ADC frequency plot (dotted line) towards the right as a result of increasing ADC values.
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