This illustration depicts blood stem and progenitor cells emerging from hemogenic endothelial cells during normal embryonic development. The left blue cells are emerging hematapoietic stem and progenitor cells. The red cells are red blood cells. Sugimura and colleagues recapitulated this natural blood development process in two steps: 1) exposing induced pluripotent stem cells (iPS cells) to chemical signals to generate the hemogenic endothelial cells, and 2) adding five genetic factors to transform the hemogenic endothelial cells into blood stem and progenitor cells. Credit: O'Reilly Science Art Foto: O'Reilly Science Art
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