rHuEPO 3 N-linked carbohydrate chains Up to 14 sialic acids 30,400 daltons ~40% carbohydrate Egrie JC, Browne JK. Nephrol Dial Transplant. 2001;16(sup
{"Image DocumentName": "Biochemical and biological properties of rHuEPO and glycosylation analogs", "Image ImageDescription": "Receptor binding. rHuEPO. 3 N-linked carbohydrate chains. Up to 14 sialic acids. 30,400 daltons. ~40% carbohydrate. 4 N-linked carbohydrate chains. Up to 18 sialic acids. 33,750 daltons. ~46% carbohydrate. Biological activity. Serum half-life. NESP. 5 N-linked carbohydrate chains. Up to 22 sialic acids. 37,100 daltons. ~51% carbohydrate. The 4- and 5-N linked chain glycosylation analogs of rHuEPO are biochemically distinct from rHuEPO. They have increased molecular weight, sialic acid content and negative charge. The two extra carbohydrate chains on Aranesp\u00ae increase the molecular weight by about 22% and the maximum number of sialic acid residues from 14 to 22. In tests of in vivo efficacy, the magnitude of the hematocrit rise correlated with the number of carbohydrate chains and the sialic acid content of the molecules. Egrie JC, Browne JK. Nephrol Dial Transplant. 2001;16(suppl 3):3-13.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}