Robbins pathologic basis of disease 10th edition has a handful of changes and updates when compared to it's predecessor. Here is a brief note on the chapterwise updates which are high yield for entrance exams. **ROBBINS 10TH EDITION CHAPTERWISE UPDATES** **CHAPTER 1- CELL** * ***Satellite DNA****- A major component of centromeres is so-called satellite DNA, consisting of large arrays—up to megabases in length—of repeating sequences (from 5bp up to 5kb). Although classically associated with spindle apparatus attachment, satellite DNA is also important in maintaining the dense, tightly packed organization of heterochromatin. * * ***Gene Editing and CRISPR- ****An exciting new development that allows high-fidelity genome editing may usher in the next era of the molecular revolution. This advance comes from a wholly unexpected source: the discovery of clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated genes (Cas), such as the Cas9 nuclease.* **CHAPTER 2- ADAPTATIONS AND INJURY** * ***Ferroptosis- ****Only discovered in 2012, ferroptosis is a distinct form of cell death that is triggered when excessive intracellular levels of iron or reactive oxygen species overwhelm the glutathione-dependent antioxidant defenses. * **CHAPTER 3-INFLAMMATION AND REPAIR** * ***Neutrophil extracellular traps (NETs)- ****NETs were mentioned in the previous edition it is further elaborated in the latest edition. Neutrophil extracellular traps (NETs) are extracellular fibrillar networks that concentrate antimicrobial substances at sites of infection and trap microbes, helping to prevent their spread.* **CHAPTER 6- IMMUNITY** * ***Rejection of tissue transplants:*** *Elaborated compared to the previous edition*. **CHAPTER 7- NEOPLASIA** * ***A few newly added proto-oncogenes: *** 1. FMS-like tyrosine kinase 3 (FLT3) Point mutation or small duplications in Leukemia. 2. GTP-binding (G) proteins- GNAQ Point mutation in Uveal melanoma. 3. GTP-binding (G) prote
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