Commitment of stem cells to the production of neurons with defined connectivity.    Stem cells located in the subventricular zone (SVZ) of adult mice are committed to generate the same neuronal type (granule cells in the olfactory bulb with defined connectivity. Stem cells located in the anterior regions of the SVZ (labeled in red) produce neurons whose dendrites reach the upper layers of the olfactory bulb. In contrast, stem cells located in the posterior SVZ (labeled in green) produce neurons whose dendrites branch in the lower layers of the OB. Our laboratory is investigating the molecules that regulate the patterns of connectivity of neurons in this brain region.
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