A simplified model of the molecular pathway. Notes: Upon stimulation by LPS, the p38 MAPK pathway is activated, and this is followed by the activation of MK2. MMI-0100 is able to inhibit the activation of p-MK2 and reduce the expression of ICAM-1. Abbreviations: LPS, lipopolysaccharides; p-MK2, phosphorylated MK2.
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