Effect of rociletinib on AKT, ERK, and their phosphorylations in MDR and the parental cells. S1 and S1-MI-80 cells were treated with different concentrations of rociletinib for 48 h. The protein expression level of AKT and ERK and phosphorylations were detected by Western blot (GAPDH as loading control). All these experiments were repeated at least three times.
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