Effect of CGRP on ATP- and ADP-induced Ca 2+ transients in trigeminal neurons. a Intracellular calcium transients evoked by 2 s application of 1 μM ATP, 50 mM KCl, and 10 μM ionomycin in trigeminal neurons in control conditions (average of 5 traces with SEM). b Transients induced by ATP, KCl, and ionomycin after 2 h exposure to 1 μM CGRP (average of 5 traces). c Quantification of CGRP effect on Ca 2+ transients activated by 1 μM ATP ( n = 40 cells) or 1 μM ADP ( n = 40 cells) in control and after CGRP exposure ( n = 84 cells in both cases). Notice that CGRP increased Ca 2+ responses to ATP. Mean ± SEM, * p
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