"Chromoanagenesis in cancer. Complex structural chromosome rearrangements in cancer, involve stepwise or punctual chromosome restructuring. It includes stepwise classic intra or inter-chromosomal break-fusion-bridge cycles (A); chromothripsis (B), which are punctual localized highly complex chromosome fragmentation (1) and rejoining (2) events, and chromoplexy (C), in which complex linked translocation events involving multiple chromosomes presumably occur simultaneously. 1 through 6 (black typeface) and 1 through 5 (orange typeface) represent two such linked ""chained"" events."
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