Post-translational modification of the lysine ε-amino group and histone deacetylase (HDAC) inhibitors. (A) Acetylation and de-acetylation of the lysine ε-amino group are mediated by histone acetyltransferases (HATs) and HDACs, respectively. (B) Pharmacophore model of HDAC inhibitors and their representative structures. SAHA, suberoylanilide hydroxamic acid; ZBG, zinc binding group.
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