A Brief History of Anticoagulant Therapy
{"Image DocumentName": "A Brief History of Anticoagulant Therapy", "Image ImageDescription": "Convenience and clinical benefit. Direct Xa inhibitors: Single target, oral. Present. Indirect Xa inhibitors: Dual target, parenteral. 2000s. 1990s. DTIs: single target, oral and parenteral. 1980s. LMWHs: multiple targets, parenteral. In summary, Very often, blood clots in the veins are formed silently and commonly after surgeries such as hip replacements or knee surgery. These silent, large clots can break away, float in the veins and then get lodged in the lungs causing what is called a pulmonary embolus, or PE for short, which is a serious, often fatal condition and is the commonest cause of sudden death after surgery. This life-threatening event could be prevented if we had the right treatment to stop the abnormal formation of blood clots, in the first place. Anticoagulants is the cornerstone of treatment and prevention of VTE. Convenient oral administration, improved specificity and direct mode of action have guided the development of anticoagulation since the discovery of heparin in the 1930s. Oral, direct Factor Xa inhibitors are part of this evolution, as they directly and specifically inhibit Factor Xa. Alban S. Eur J Clin Invest. 2005;35(Suppl 1): s. VKAs: multiple targets, oral. 1930s. UFH: multiple targets, parenteral. DTIs, direct thrombin inhibitors. Alban. Eur J Clin Invest 2005.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}