SYK inhibition by entospletinib (E) and fostamatinib (F) reduces <t>p53</t> level (D). HCT116 and HT1080 cells were treated with 1.5 μM doxorubicin or 1 μM doxorubicin (D) and 1 μM entospletinib or 0.5 μM fostamatinib for 24 hours. Entospletinib and fostamatinib reduced p53 levels in both cell lines. Error bars showed p53 and SYK quantification from different experiments.
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