Pharmacokinetic Changes of Aging
{"Image DocumentName": "Pharmacokinetic Changes of Aging", "Image ImageDescription": "Absorption. Though numerous structural and physiological age-related changes in the GI tract exist, they are of minimal clinical significance in the absence of gastrointestinal pathology. Decreased first-pass after oral administration \u2013 morphine, isosorbide dinitrate (Isordil ) Heart failure can affect the absorption of some medications including furosemide (Lasix ) Effects of aging on percutaneous, subcutaneous and intramuscular absorption is largely unknown but in states of poor perfusion expect delayed or incomplete absorption. Distribution (volume of distribution) Body Composition Changes. Lean-to-fat ratio altered \u2013 digoxin (Lanoxin ) Decreased total body water - lithium. Protein concentration changes \u2013 warfarin (Coumadin )", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}