 Dual antiplatelet Rx (ASA + thienopyridine) is standard of care: Ticlopidine Clopidogrel Ticlopidine Clopidogrel  Clinical need to improve on benefits observed with clopidogrel  Prasugrel Novel thienopyridine Efficient generation of active metabolite High levels of IPA achieved rapidly High levels of IPA achieved rapidly High IPA in clopidogrel hyporesponders Encouraging Phase 2 data
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