Brain exosome levels are lower in human APOE4 -carriers compared with homozygous APOE3 individuals. ( A ) Extracellular vesicle protein levels from human brains normalized to brain tissue weight. ( B ) A representative western blot showing ALIX and TSG101 (exosomal proteins), and flotillin-1 (a lipid-raft enriched protein) in the extracellular vesicles. ( C ) Quantification of band intensities normalized to brain tissue weight is shown for levels of ALIX, TSG101, and flotillin-1. Data are expressed as the mean ± SEM of the ratios of APOE4 carriers to APOE3 . * P
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