European Commission - DG Environment HealthEnvironment 1-10t prioritised  In vitro skin and eye irritation  Skin sensitiation  In vitro mutagenicity  Acute toxicity (one route)  Acute aquatic toxicity – Daphnia  Biodegradation – biodegradability and hydrolysis  Acute aquatic toxicity – Algae 10- 100t  In vivo skin and eye irritation  Further in vitro mutagenicity  Sub acute toxicity (28 days)  Reproductive toxicity screen  Acute aquatic toxicity – Fish  Activated sludge  Adsorption/desorption screening 100- 1000t  Further mutagenicity tests  Sub-chronic toxicity (90-days)  Further reproductive toxicity tests  Long term aquatic toxicity daphnia and fish  Further degradation and fate/behaviour studies  Short term effects on terrestrial organisms >1000t  Further mutagenicity tests  Carcinogenicity  Chronic toxicity  Further reproductive toxicity tests  Further degradation and fate/behaviour studies  Long term effects on terrestrial organisms Registration Requirements (2)
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