Weill Medical College of Cornell University Published double-blind, placebo-controlled studies: SSRI efficacy for MDD Studies of children & adolescents: Emslie et al (1997): modest fluoxetine efficacy: fluoxetine 58%, placebo 32% Keller et al (2001): paroxetine efficacy: paroxetine 63%, imipramine 50%, placebo 46%, 1 of 2 primary outcome measures was significant; 2 other studies were negative Emslie et al (2002): fluoxetine efficacy: effects modest (fluoxetine 41%, placebo 20%) & not all outcome measures were significantly different than placebo Wagner et al (2003): sertraline efficacy: sertraline 69%, placebo 59%
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