28 Adaptive Designs Working Group Objective: testing two hypotheses with given significance level and power at the specified alternative, prefixed max
{"Image DocumentName": "Group Sequential Designs", "Image ImageDescription": "Objective: testing two hypotheses with given significance level and power at the specified alternative, prefixed maximum sample size. AR: fixed randomization. SaR: after a fixed number (a group) of observations, or using error-spending function, or using Christmas-tree adjustment. StR: boundary crossing. Haybittle, Pocock, O\u2019Brien-Fleming type. linear boundaries. error-spending families. conditional power, stochastic curtailment. DR: final decision - to accept or reject the null hypothesis. References: Jennison&Turnbull (2000); Whitehead (1997)", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}