40 Adaptive Designs Working Group Seamless Designs Two-stage adaptive designs 1 st Stage: treatment (dose) selection – learning 2 nd Stage: comparison
{"Image DocumentName": "Seamless Designs Two-stage adaptive designs", "Image ImageDescription": "1st Stage: treatment (dose) selection \u2013 learning 2nd Stage: comparison with control \u2013 confirming Treatment selection may be based on a short-term endpoint (surrogate), while confirmation stage uses a long-term (clinical) endpoint. 2nd Stage data and the relevant groups from 1st Stage data are combined in a way that. Guarantees the Type I error rate for the comparison with control. Produces efficient unbiased estimates and confidence intervals with correct coverage probability.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}