Effect of an mGluR antagonist and modulators of second messenger pathways on the mGluR-induced potentiation of NMDA receptors. Outlier box plots showing the amplitude of NMDA-induced calcium responses measured as Δ F / F. A, The mGluR antagonist CPCCOEt blocked the DHPG-induced potentiation of NMDA-induced calcium response. B, The potentiation persisted in the presence of the protein kinase inhibitor H-7. C, The potentiation persisted in the presence of the protein kinase inhibitor H-8. D, <t>Ryanodine</t> had no effect on the potentiation of NMDA response by DHPG.
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