Effects of the high extracellular Ca2+ concentration ([Ca2+]o) on the [Ca2+]i of gingival fibroblasts. Application of Ca2+ (2–10 mM) in the perfusion buffer concentration dependently elevated the [Ca2+]i. The upper trace shows a time course of the [Ca2+]i. Data are mean ± SEM, N = 20. ***P < 0.005, ****P < 0.001 compare to corresponding pretreated values
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