Metabotropic Glutamate Receptors: The Fine Print –Seven transmembrane domains G-protein coupled Similar to most dopamine, serotonin, noradrenaline receptors Activate phospholipase C or inhibit adenylate cyclase –Type I—post-synaptic Occur in hippocampal, amygdala, and thalamic neurons Less in the cortex and ventral striatum –Types II and III—presynaptic modulators of glutamate release Type II mGluR2 restricted to the cortex and dentate gyrus mGluR3 only metabotropic subtype expressed on glia Tsapakis EM, Travis MJ.
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