Solubility measurement: Shake-flask vs. pH-metric
{"Image DocumentName": "Solubility measurement: Shake-flask vs. pH-metric", "Image ImageDescription": "Chlorpromazine. All sample dissolved. Value of logS is reliable until this point, above which all sample dissolved logS pH. Line calculated using pKa = 9.24, log S0 = -5.07, pH-metric data obtained using Sirius GLpKa, D-PAS and CheqSol. Sample weight 9.89mg [3] Points represent concentrations after precipitate removed from 12 buffered solutions containing 0.5% of 10mM sample in DMSO. Total sample weight 0.38mg. [3] Box, K J. V\u00f6lgyi, G. Baka, E. Stuart, M. Tak\u00e1cs-Nov\u00e1k, K. Comer, J. Equilibrium vs. kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution - a validation study J. Pharm. Sci. submitted. /35.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}