Quantification of buffer-soluble and insoluble Aβ in the cerebrum by the Aβ40- and Aβ42-specific ELISA. The cerebral buffer-soluble Aβ40 content in Tlr Lps-d / Tlr Lps-d mice is higher than that in TLR4 wild-type mice ( A ). The cerebral buffer-soluble Aβ42 content in Tlr Lps-d / Tlr Lps-d mice is higher than that in Tlr Lps-d / θ mice ( B ). The amount of total buffer-soluble Aβ (Aβ40 + Aβ42) is higher than that in TLR4 wild-type mice ( C ). The cerebral insoluble Aβ40 content in Tlr Lps-d / Tlr Lps-d mice is higher than that in Tlr Lps-d / θ mice ( D ). The cerebral insoluble Aβ42 content in Tlr Lps-d / Tlr Lps-d mice is higher than that in TLR4 wild-type mice ( E ). The amount of total insoluble Aβ (Aβ40 + Aβ42) in Tlr Lps-d / Tlr Lps-d mice is higher than that in TLR4 wild-type mice ( F ).
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