Vitamins and Supplements Limited evidence to be continued at end of life Offer little or no additional palliative benefit Increased pill burden o Troublesome for patients with difficulty swallowing Increased potential for drug-drug interactions o Calcium and iron can decrease absorption of other medications o Many herbal supplements increase bleeding risk with concomitant anticoagulants/anti-platelet medications Increased potential for side effects o Iron supplements can worsen constipation and nausea
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