Benefits: Menopausal hormone therapy
{"Image DocumentName": "Benefits: Menopausal hormone therapy", "Image ImageDescription": "In studies of postmenopausal women in general, MHT   reduces the risk of vertebral, nonvertebral, and hip fractures. Strength of Evidence: High. In postmenopausal women with established osteoporosis, MHT does not reduce fracture risk significantly. Strength of Evidence: Moderate. No differences in comparative effectiveness for fracture prevention have been shown between bisphosphonates and MHT (estrogen) No differences in fracture incidence have been shown in comparisions of patients treated with MHT and either raloxifene or vitamin D. Strength of Evidence: Low. Benefits: Menopausal Hormone Therapy. In studies of postmenopausal women in general, MHT reduces the risk of vertebral, nonvertebral, and hip fractures. The strength of evidence for this finding is high. However, in postmenopausal women with established osteoporosis, MHT does not reduce fracture risk significantly. The strength of evidence for this conclusion is moderate. No differences in comparative effectiveness have been shown between bisphosphonates and MHT in preventing fractures (Strength of Evidence: Moderate). In addition, no differences in fracture incidence have been shown between patients treated with MHT and raloxifene or vitamin D (Strength of Evidence: Low). As a footnote to this evidence, it is important to note that the Women\u2019s Health Initiative (WHI) reported serious adverse events associated with MHT, such that routine use of hormone replacement therapy in postmenopausal women is now discouraged. Reference: Newberry SJ, Crandall CC, Gellad WG, et al. Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update to the 2007 Report. Comparative Effectiveness Review No. 53 (Prepared by the Southern California Evidence- based Practice Center under Contract No. HHSA I). Rockville, MD: Agency for Healthcare Research and Quality; February AHRQ Publication No. 12-EHC023-EF. Available at   The Women\u2019s Health Initiative reported serious adverse events associated with MHT, such that routine use of hormone replacement therapy in postmenopausal women is now discouraged. Crandall CC, Newberry SJ, Gellad WG, et al. Comparative Effectiveness Review No. 53. Available at:", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}