Logic of 5-HT role in macronutrient selection
{"Image DocumentName": "Logic of 5-HT role in macronutrient selection", "Image ImageDescription": "A high-carb diet leads to \uf0e9 circulating tryptophan (TRP). Promotes uptake of TRP into brain, conversion into 5-HT. \uf0ea concentrations of other amino acids that compete with TRP for transport into brain. LNAAs and TRP compete for BBB passage across LNAA transporter (which carries branched-chain AAs (Valine, Leucine, Isoleucine) and aromatic (TRP, TYR) AAs. Transport is rate-limiting step in blood-brain tissue movement of aas. Tryptophan-> 5-hydroxytriptophan-> 5-hydroxytriptamine (fig 4.16) Insulin promotes use of LNAAs by skeletal muscles, leaving relatively more TRP to cross BBB. 5-HT neurons project from Raphe to.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}