#3 METABOLISM Biotransformation: process by which the body changes the chemical structure of a drug to another form called a metabolite.
{"Image DocumentName": "#3 METABOLISMBiotransformation: process by which the body changes the chemical structure of a drug to another form called a metabolite.", "Image ImageDescription": "Metabolite: a more water soluble compound that can be easily excreted. The major organ for this process is the liver. Some water soluble drugs can be excreted by the kidneys in unchanged form. 2. If fat soluble drugs were not metabolized to more easily excreted forms, they. could stay in the body for years. 3. Biotransformation does not necessarily yield a compound without pharmacological. activity, but generally results in one that is less fat soluble and, as a result, more. easily excreted. 4. Drugs exposed to liver biotransformation may be eliminated from the body before the opportunity to be exposed to tissue sites of action. (First pass phenomenon) Presystemic Metabolism - gastrointestinal acid and enzymes, bacterial action, and enzymes in the wall of the. intestine are all potential sites of metabolism of drugs before they can be absorbed. Hepatic Microsomal Enzyme System - an important class of liver enzymes responsible for the metabolism of many chemicals, including drugs, insecticides, food additives and chemical pollutants.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}