Acute Radiation Syndrome (Cont
{"Image DocumentName": "Acute Radiation Syndrome (Cont", "Image ImageDescription": "Acute Radiation Syndrome (Cont.) Hematopoetic Component - Latent Period From Weeks to Days. Dose ~ 500 rem. ~50% mortality with supportive care. Dose ~ 1000 rem % mortality despite supportive care. 53 Neutrophil Count: The neutrophil count is the best predictor of subsequent clinical infection. Exposures in the range of 1.0 Gy result in only a mild decrease of the neutrophil count. Exposures of up to 2.0 Gy will result in a 50 percent decrease in the neutrophil count. In contrast to the lymphocyte count, the decrease in neutrophils is gradual, reaching its nadir at four to six weeks post exposure. At greater exposures 2-6 Gy the neutrophil count may actually rise in the first several days followed by a fall. This fall may be quite precipitous, dropping to 50 percent or less of normal counts by one-week post exposure. In a patient with more significant radiation exposure, there may be a plateauing of the neutrophil counts or even a transient rise at one to two weeks. This is almost invariably followed by a further decrease in the neutrophil count. If the patient survives, recovery of neutrophils is noted between the sixth and eighth weeks post exposure. As in chemotherapeutic regimens, patients should receive appropriate 3 antibiotic coverage and isolation when the neutrophil counts become dangerously low. Susceptibility to opportunistic organisms may occur in this population as well. Platelet Count: As with the other formed blood elements, the effect on platelet count is related to the exposure level. Larger exposures will result in a decrease in the platelet count beginning within the first week or two-post exposure. Lower levels of exposure will manifest changes at four weeks.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}