Increase in seizure threshold temperature after CUR-1901 treatment. Scn1a E1099X/+ (a) or WT (b) mice were treated with 4 weekly injections of CUR-1901 at 20 μg/injection or saline. ( n = 4.6, representative of 3 experiments, t -test p = 0.01). (c) Cumulative seizure probability vs core body temperature for WT and Scn1aE1099X/+ transgenic mice treated with CUR-1901 or vehicle ( n = 3.3,6,5 respectively, representative of 3 experiments). (d) Power spectra of normal EEG (red trace), inter-ictal EEG (green trace), ictal EEG (blue trace) and post-ictal suppression EEG (black trace) in Scn1aE1099X/+ transgenic mice ( n = 6).Mean ± S.E.M. ** — p
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