Dacarbazine  Dose: 800-1000 mg/m2 IV over 5-8 hours q2-3 weeks Pretreat with Cerenia Pretreat with dexamethasone to prevent phlebitis Pretreat with opiate to prevent pain on IV infusion  Indications: LSA Rescue, ST sarcoma, melanoma  Unique Side Effects: Serious extravasation injury, like Actinomycin D Hepatoxicity and nephrotoxicity - use with caution with hepatic or renal disease Photosensitivity Dilute to prevent pain on IV infusion (D5W or saline)
{"Image DocumentName": "Procarbazine Drug Interactions:", "Image ImageDescription": "Potentiates activity of CNS depressants. anticonvulsants, opiates, sedatives, antihistamines, antihypertensives, tricyclic antidepressants. Serious hypertension if given with sympathomimetics. Phenylpropanolamine. Avoid foods high in tyramine \u2013 aged cheese, yogurt, bananas. Contraindications: any of the above drugs. Handling: OK to compound into capsules, but liquids must be oil based.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}