Discovery Models: Oxygen Exposures (Yeast/C. elegans, Mouse strains, Human cells, Human in vivo/Clinical) heads to Comparative Genomics. Both Comparative Genomics and Existing Model Studies head to Candidate Genes. Candidate Genes leads to two sections: Mechanism-Based Functional Exposure Models (Yeast/C. elegans, Mouse, Human cells) and Disease Model (Gene-environment interaction studies of lung disease, susceptibility/prognosis in O2-exposed neonates). The double arrow indicates that the two sections are interconnected. Mechanism-Based Functional Exposure Models and Disease Model lead to Test in OS-Related Diseases, which will occur in the future. Mechanism-Based Functional Exposure Models also leads to Mechanism-Based Therapeutic Hypotheses, which in turn, leads to Prevention Trial. The latter two indicate long-range future plans.
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