High-throughput sequencing technologies
{"Image DocumentName": "High-throughput sequencing technologies", "Image ImageDescription": "Potential applications - GENOME LEVEL HTP de novo sequencing Facilitated sequencing of related genomes Resequencing - genetic diversity and evolutionary studies: - genome-wide discovery of genetic polymorphisms - Low-cost alternatives to whole-genome resequencing: Environmental sequence analysis Detection of rare somatic mutations (somaclonal variation) - TRANSCRIPTOME LEVEL Transcript discovery and gene expression profiling Accurate gene annotation ( splicing sites) Deep sequencing of small RNAs (miRNA, si RNAs, etc) DNA Methylation profiling (BS-seq, methylC-seq) ChIP sequencing: DNA protein binding sites analysis Epigenome analysis ( nucleosome mapping, analysis of epigenetic processes, etc) Limitations Cost. Danger of simplistic views on research. Needs some thinking Consulted experts : P Wincker, G\u00e9noscope.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}