IFN-alpha but not IFN-lambda1 promote Th1 responses and block Th2 responses in activated cord CD4+ T-cells.Cord blood CD4+ T-cells were activated with anti-CD3 (A–B) or anti-CD3 and anti-CD28 (C) in the presence or absence of recombinant human IFN-alpha or IFN-lambda1. Supernatants were collected after 48 h and analyzed for IFN-gamma (A), IL-5 (B) and IL-13 (C) content. Data are expressed as medians and the 25% and 75% percentile (the boxes) with the minimum and maximum responses for n = 5. *  =  p<0.05 using ANOVA with Bonferroni's multiple comparison test.
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