Addiction Neurobiology Prefrontal cortex (PFC), especially the anterior cingulate gyrus (AC) and orbital prefrontal cortex (OPC): Areas of the brain recruited by emotionally relevant events (ERE) and predictors of them (dopamine mediated) Prefrontal cortex (PFC), especially the anterior cingulate gyrus (AC) and orbital prefrontal cortex (OPC): Areas of the brain recruited by emotionally relevant events (ERE) and predictors of them (dopamine mediated) Involved in the evaluation of salience of the stimuli and the choice of behavioral response and it's intensity (glutamate mediated).
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