Interplay between HIF-1α and p53 in anoxia.(A) Bifurcation diagrams of [p53pac] (red), [HIF-1αac] (blue) and [Mdm2n] (green) versus the amount of p300. (B) Bifurcation diagrams of [p53pac] (red), [HIF-1αac] (blue), [Mdm2c] (green) and [Mdm2n] (pink) versus the p53-induced production rate of Mdm2, ksmdm2. (C) Bifurcation diagrams of [HIF-1αac] (blue, on the right axis), [p53pac] (red) and [PUMA] (green) versus the production rate of HIF-1α, kshif. (D) Bifurcation diagrams of [HIF-1αac] (blue), [p53pac] (red) and [PUMA] (green) versus the production rate of p53, ksp53.
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