Forty-eight mice were equally divided into 8 groups. *Significant increase of nitric oxide in nicotine group compared to saline group (P < 0.05). **Significant decrease in all groups of crocin administration compared to nicotine group (P < 0.05). ***Significant decrease in all groups of crocin-nicotine administration compared to nicotine group (P < 0.05). The numbers above the columns of the chart are mean ± standard error of triplicate experiments
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