Clinical and Therapeutic Implications of Cholinergic hypothesis
{"Image DocumentName": "Clinical and Therapeutic Implications of Cholinergic hypothesis", "Image ImageDescription": "Recent functional MRI study demonstrated MCI treated with donepezil demonstrated increased frontal cortex activation relative to untreated control. Correlated with task performance. AChE does not show decline until late stages of disease. Only mild losses in MCI and mild AD. Vesicular Ach transporter is not severely altered in AD. Cholinergic neurons appear then to shrink and become dysfunctional rather than degenerate early in disease. Suggest cholinergic neurons may be viable, however dysfunctional early in disease and thus amenable to manipulations. Changes in neurotrophic gene expression may provide targets of intervention for dysregulation of cholinergic neurons. NGF (trk) receptors down-regulation may be a molecular marker for transition from MCI to frank AD. Saykin et al, 2004, Bierer et al 1995, Rinne et al, 2003, Gilmor et al, 1999, Rinne et al 1987, Mufson et al, 2009.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}