Signalling pathways mediating the effects of HDL on endothelial NO productionHDL has been shown to stimulate endothelial NO synthase phosphorylation at serine residue 1177 via binding of apoA-I to SR-BI and binding of HDL-associated lysophospholipids to the S1P3 receptor. In addition, HDL-mediated efflux of 7-oxysterols via endothelial ABCG-1 has been observed to inhibit the interaction between eNOS and caveolin, and to prevent the loss of eNOS dimerization induced by reactive oxygen species in the endothelium.
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