Apoptotic cells in the splenic white pulp of WT and TNF-α KO mice after intranasal S. pneumoniae infection. WT (A, C, E) and TNF-α KO (B, D) mice at 0 (A, B), 48 (C, D), and 72 h (E) post-infection. Apoptotic cells were quantified and expressed as the means±SD/mm2 (F). **P<0.01 compared with WT mice.
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