Effects of a PTP1B inhibitor, an SHP1/2 inhibitor and stibogluconate on cADPR-induced increase in resting [Ca 2+ ] i in isolated rabbit ventricular myocytes ( a ) and isolated SR vesicles ( b ). ( a ) Fura 2- AM loaded myocytes were incubated with 8 μ M PTP 1B inhibitor, 300 n M SHP1/2 PTPase inhibitor or 11 μ M sodium stibogluconate for 10 min before perfusion with cADPR. Columns with vertical bars represent a quantitative summary of the maximum [Ca 2+ ] i increase after cADPR addition from five experiments. * P
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