Endochondral Bone Development
{"Image DocumentName": "Endochondral Bone Development", "Image ImageDescription": "1. Most of the bones of the skeleton fall into this category. 2. They first develop as hyaline cartilage models and are then replaced with bone. 3. Cartilage is broken down in the diaphysis and progressively replaced with bone while the periosteum develops on the outside. 4. Cartilage tissue is invaded by blood vessels and osteoblasts that first form spongy bone at the primary ossification center in the diaphysis. 5.Osteoblasts beneath the periosteum lay down compact bone outside the spongy bone. 6.Secondary ossification centers appear later in the epiphyses. 7. A band of hyaline cartilage,the epiphyseal plate,forms between the two ossification centers. 8.Layers of cartilage cells undergoing mitosis make up the epiphyseal plate. 9.Osteoclasts break down the calcified matrix and are replaced with bone building osteoblasts that deposit bone in place of calcified cartilage. 10. Epiphyseal plates are responsible for lengthening bones while increases in thickness are due to intramembranous ossification underneath the periosteum. 11. A medullary cavity forms in the region of the diaphysis due to the activity of osteoclasts.   Basically, occurs in the epiphyseal plates, the cartilage is covered to bone as the cartilage becomes calcified (filled with calcium) causing it to get hard. The growth occurs from the middle outward to increase length (growth in height)", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}